Module Descriptions

Process Engineering (MPE)

Biotechnological Processes

Empfohlene Vorkenntnisse

Strömungsmechanik, Apparatebau, Biologie, Grundlagen der Biotechnologie, Grundlagen der Prozessmodellierung und -simulation.

Lehrform Vorlesung/Seminar/Labor
Lernziele / Kompetenzen

Die Studierenden erwerben ein ganzheitliches Verständnis für biotechnische Prozesse und deren technische Umsetzung. Durch Bearbeitung verschiedener Teilbereichen gemeinsamer Projekte durch Untergruppen wird die Teamfähigkeit der Studierenden gefördert. Im Technikum erstellen die Studierenden auf Basis von Betriebsanleitungen, aber ohne detaillierte Versuchsanleitungen, für ihre jeweilige Gruppe eigene Versuchskonzepte. Im Hinblick auf Tätigkeiten in Wissenschaft und industrieller Forschung und Entwicklung lernen sie zu akzeptieren, dass sich nicht alle Gedanken und Konzepte im Rahmen der zur Verfügung stehenden Mittel und im gegebenen Zeitrahmen als umsetzbar, oder wenn zwar umsetzbar, im Nachherein auch als sinnvoll erweisen.

Learning Target and Competences
Die students obtain an integral and comprehensive understanding of biotechnical processes and their technical realization. By means of small groups working on various partial aspects of a common project their capacity for teamwork is promoted. For example in the laboratory the students, within their group, are encouraged to work out their individual experimental programme. In view of carrying scientific work or indutrial research and development they learn to accept that not all ideas and concepts can be realized within the framework of given means and time, or if realizable that in retrospect it may not have been useful.

Dauer 1
SWS 10.0
Aufwand
Lehrveranstaltung 130
Selbststudium / Gruppenarbeit: 170
Workload 300
ECTS 10.0
Leistungspunkte Noten

Dimensioning Fermenters = Klausur 90 Minuten (written test 90 minutes)

Wahllabore (elective labs) Technical School Fermentation / Technical School Scale-up of Mixing Processes = Laborarbeit (laboratory report)

Modulverantwortlicher

Prof. Dipl.-Ing. Torsten Schneider, Ph.D.

Max. Teilnehmer 10
Empf. Semester MPE1
Haeufigkeit jedes Jahr (WS)
Verwendbarkeit

Master MPE

Veranstaltungen

Dimensioning Fermenters

Art Vorlesung/Seminar
Nr. M+V903
SWS 4.0
Lerninhalt
  • biological aspects of fermenter design
  • biological kinetics
  • bioreactor modelling
  • flow patterns in stirred tanks, rheology of fermentation broths
  • principles of flow simulation
  • scaling-up of mixing processes
  • mechanical design of fermenters
Literatur
  • Biological Reaction Engineering; Dunn, I.J.; Heinzle, E.; Ingham, J.; Prenosil, J.E.;Wiley-VCH, 2003
  • Practical Fermentation Technology; McNeil, B.; Harvey, M.; John Wiley & Sons, 2008
  • Bioseparation and Bioprocessing; Subramanian, G.; 2nd edition Wiley VCH, 2007
  • Handbook of Mixing; ed. EKATO; 1991
  • Ähnlichkeitsgesetze und Modellregeln; J.Zierep; Braun Verlag, Berlin, 1991
  • Ullmann`s Biotechnology and Biochemical Engineering; Wiley VCH 2007
  • O. Levenspiel; The Chemical Reactor Omnibook; script 1979

Technical School Fermentation

Art Labor/Studio
Nr. M+V905
SWS 4.0
Lerninhalt

1. Continuous fermentation

  • Prearrangements and preculturing
  • Measurement principles of a bioreactor
  • Continuous cultivation process with flow rate shift and substrate shift
  • Modelling and simulation of the continuous cultivation process (instationary and stationary conditions)
  • Data evaluation and discussion, comparison of experimental and simulated data

2. Immobilized biocatalysts

  • Crosslinking and co-crosslinking (enzymes)
  • Entrapment (co-crosslinked enzymes and cells)

 

Literatur

1. McNeil, B.: Practical Fermentation Technology. John Wiley & Sons 2008

2. Dunn, I.J.; Heinzle, E.; Ingham, J.; Prenosil, J.E.: Biological Reaction Engineering - Dynamic Modelling Fundamentals with Simulation Examples, 2nd completely revised edition. Wiley-VCH, 2000

3. Guisan, J. M.: Immobilization of Enzymes and Cells (Methods in Biotechnology), Second edition. Springer 2006

Technical School Scale-up of Mixing Processes

Art Labor/Studio
Nr. M+V925
SWS 4.0
Lerninhalt

In open mixing vessels the hydromechnical conditions in stirred tanks are visualized by means of model liquids. Possible topics of investigation:

  • development of model liquids with similar rheological properties like fermentation broths
  • selection of a suitable stirrer, determination of required speeds and power inputs
  • rheology:correlation between viscosity curves of liquids and viscosities effective in stirred tanks
  • measurement of the effect of viscosity on mixing time and mass transfer in model liquids
  • determination of the shear sensitivity of microorganisms and liquids containing organic components
  • development of scale-up rules for selected mixing processes in two different scales (3 and 30 litres volume)
Literatur
  • Handbook of Mixing; ed. EKATO; Schopfheim 1991
  • Ähnlichkeitsgesetze und Modellregeln; J.Zierep; Braun Verlag, Berlin, 1991
  • Bulut, S.; Waites, W.M.; Mitchell, J.R.: Effects of Combined Shear and Thermal Forces on Destruction of Microbacterium lacticum; Applied and Environmental Microbiology, Vol. 65, No. 10/1999, p. 4464-4469